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Comment: Migrated to Confluence 5.3

The Drug Related Gene Database (DRG), or DRG is funded by National Institute of Drug Abuse (NIDA) ARRA Supplement #HHSN27120080035C, the DRG database was created to facilitate discovery and use of resources relevant to drug abuse research.  The database and associated tools were specifically created for providing data that is contained in tables, figures and supplementary materials from published papers in a way that facilitates search across the results of these studies.  These data are extracted from published journal articles that directly test hypotheses relevant to the neuroscience of addiction and addictive behavior.  The current database mainly focuses on gene expression data and exposes data from investigations using DNA microarrays, polymerase chain reaction, immunohistochemistry and in-situ hybridizations. Data types include the effects of a particular drug, strain, or knock out on a particular gene, in a particular anatomical region. Once loaded, these data are available for query through the NIF interface.  During this process, the content is standardized using a generic high level description of a relevant study and terms are mapped to ontologies available through the NIF project (NIFSTD) to enhance semantic search of such data. 

Table of Contents:

Table of Contents

Publications whose tables are available through DRG

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Table 3. Results DNA-microarrays: naloxone precipitated morphine withdrawal vs. saline treatment (control)

  • Expression pattern of NuIP gene in adult mouse brain.

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Table 2. Brain CYP2D protein immunocytochemical staining in saline- and chronic nicotine-treated monkeys

  • Transcriptional responses to reinforcing effects of cocaine in the rat hippocampus and cortex.

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Table 2: Reverse transcriptase--polymerase chain reaction confirmation for selected genes changed after cocaine CPP treatment in the hippocampus and cortex

  • Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics.

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Table 6 - Genes differentially expressed in the alcoholic NA in major functional groups.

  • Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence.

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Supplemental Table 4. All genes differentially expressed by the interaction of schizophrenia x smoking

  • Gene expression in human alcoholism: microarray analysis of frontal cortex.

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Table 4. Genes That Meet the Criteria for Differential Expression on the Oligonucleotide (A-1, A-2) Arrays

  • Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics.

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Table 5 - Differential expression values for genes involved in specific signaling processes

  • Gene expression profiling in the striatum of inbred mouse strains with distinct opioid-related phenotypes.

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Additional data file 3 - Detailed description of Gene Ontology analysis presented in Table 1 and Table 2.

  • Microarray analysis of genes expressed in the frontal cortex of rats chronically treated with morphine and after naloxone precipitated withdrawal.

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Table 3. Results DNA-microarrays: naloxone precipitated morphine withdrawal vs. saline treatment (control)

  • Precipitated morphine withdrawal stimulates multiple activator protein-1 signaling pathways in rat brain.

TABLE 1 - Relative lntensity of c-fos mRNA signals in rat brain 1 hr after naloxone-precipitated morphine withdrawal

  • Expression pattern of NuIP gene in adult mouse brain.

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